Autonomic regulation of cutaneous vascular resistance in the bullfrog Rana catesbeiana.

نویسندگان

  • G M Malvin
  • C Riedel
چکیده

To gain a better understanding of the regulation of cutaneous blood flow in the bullfrog, the vascular innervation, vasoactivity and adrenoceptor types of the cutaneous vasculature were investigated using a pump-perfused skin preparation. Stimulation of cranial nerve I, the vagal ganglion, sympathetic ganglion 1 and sometimes sympathetic ganglion 2 caused cutaneous vascular resistance (CVR) to increase. Stimulation of cranial nerve IX and spinal nerves 1 and 2 had no effect on CVR. The response to stimulation of sympathetic ganglion 1 was antagonized by phentolamine but not by atropine. Phentolamine, atropine and alpha,beta-methylene ATP had no effect on the response to vagal stimulation. Both epinephrine (EPI) and norepinephrine (NE) increased CVR, with EPI being more potent than NE. The minimum concentrations of EPI and NE required for a significant change in CVR were much higher than plasma catecholamine levels reported for resting bullfrogs. Phentolamine antagonized, but propranolol had no effect on, the responses to the catecholamines. Isoproterenol caused small decreases in CVR which were abolished by propranolol. Acetylcholine was a weak vasodilator. The results indicate that the cutaneous vasculature has two types of vasomotor nerves: sympathetic nerves that are probably adrenergic, and other nerves that are non-adrenergic/non-cholinergic and which do not use ATP as a transmitter. Although catecholamines are vasoactive, the sensitivity of the cutaneous vasculature to EPI and NE is probably too low to allow a direct regulatory role of these hormones on CVR. There is no evidence for cholinergic regulation of CVR. Both alpha- and beta-adrenoceptors are present in the cutaneous vasculature. alpha-Adrenoceptors mediate the constrictor responses to sympathetic nerve stimulation and catecholamine administration. It is unlikely that beta-adrenoceptors play a significant role in regulating CVR.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Sodium and chloride transport in tadpoles of the bullfrog Rana catesbeiana.

ALVARADO, RONALD H., AND ANNE MOODY. Sodium and chloride transport in tadpoles of the bullfrog Rana catesbeiana. Am. J. Physiol. 218(5): %1510-1516. 1970.-Unfed bullfrog tadpoles actively transport sodium and chloride ions into their body fluids from a dilute bath. The rate of exchange is about 1 pmole/lO g-hr for each ion. This can be enhanced by salt depletion. Sodium and chloride can be tran...

متن کامل

Microhabitat Preferences of Bullfrog Tadpoles (Rana catesbeiana) of Different Ages

I experimentally investigated the habitat use preferences of bullfrog (Rana catesbeiana) tadpoles of different ages (early, first-year vs. late, second-year, premetamorphic) in the laboratory. Early tadpoles showed a preference for non-vegetated areas, whereas late tadpoles showed no preference. Early tadpoles were seen more often over small, gravel substrate as opposed to large rocks, whereas ...

متن کامل

Ontogeny of heart rate regulation in the bullfrog, Rana catesbeiana.

Heart rate (fH) at 20-23 degrees C was recorded in six different developmental stages of the bullfrog, Rana catesbeiana (n = 104, body mass 40 mg to 90 g), at rest after normoxic acclimation, during acute changes in O2 availability, and after brief but intense activity. The effects of cholinergic blockade and combined cholinergic and beta-adrenergic blockade on the response to this experimental...

متن کامل

Bullfrog (rana Catesbeiana) Invasion of a California River: the Role of Larval Competition

I studied the invasion of Rana catesbeiana (the bullfrog) into a northern California river system where bullfrogs are not native. Native yellow-legged frogs, Rana boylii, a species of special concern, were almost an order of magnitude less abundant in reaches where bullfrogs were well established. I assessed the potential role of larval competition in contributing to this displacement in a seri...

متن کامل

New Trends on Antineoplastic Therapy Research: Bullfrog (Rana catesbeiana Shaw) Oil Nanostructured Systems.

Bullfrog oil is a natural product extracted from the Rana catesbeiana Shaw adipose tissue and used in folk medicine for the treatment of several diseases. The aim of this study was to evaluate the extraction process of bullfrog oil, to develop a suitable topical nanoemulsion and to evaluate its efficacy against melanoma cells. The oil samples were obtained by hot and organic solvent extraction ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of experimental biology

دوره 152  شماره 

صفحات  -

تاریخ انتشار 1990